Real-Time Molecular Insight

Northstar Response®-Informed Treatment Summary‍

BACKGROUND

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RESULTS

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TAKEAWAY

Longitudinal sampling and observed changes in TMS provided real-time insight into this patient’s treatment response and helped optimize therapeutic strategy at several key time-points.

Molecular progression detected by Northstar Response showed correlation with clinical progression across multiple monitoring intervals, demonstrating its capability as a convenient compliment to imaging. The assay’s ctDNA methylation-based approach enables precise, real-time monitoring of treatment response dynamics, evidenced by the quantitative TMS increase observed during the peri-operative treatment pause ( ) that aligns with expected tumor burden change.

After restarting treatment, the latest TMS result demonstrated a 4.1-fold decrease compared to the previous collection date, an indicator of decreased tumor burden.

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