Northstar Select CH™
Avoid false signals from clonal hematopoiesis (CH).
accuracy on CH calling for clinically actionable variants1
Introducing a panel-wide CH filter powered by ultra-sensitive buffy-coat (WBC) sequencing of CH-prone, clinically actionable genes recommended by guidelines2,3, with proprietary machine-learning classification for all other genes.
What is Clonal Hematopoiesis (CH)?
CH is primarily a natural, age-related accumulation of somatic mutations in hematopoietic stem cells. Also termed ‘CH of indeterminate potential’ (CHIP), this refers to certain driver mutations that are derived from non-tumor origins.4
Treat with confidence.
The prevalence varies by tumor type and can occur at a wide range of VAF. Proper attribution is critical, as non–tumor-derived alterations are not expected to respond to targeted therapies in the same way as true somatic tumor mutations, potentially exposing patients to unnecessary toxicity and ineffective treatment.
For clinically actionable DNA repair genes (PARPi genes), buffy-coat (white blood cell) sequencing is recommended in guidelines2,3 to rule out CH.
How Northstar Select CH™ works
Northstar Select CH™ is designed to seamlessly integrate into the existing Northstar Select® testing workflow, as an add-on test at the time of initial order
What clinicians receive
Unparalleled accuracy
with panel-wide assessment of CH
Clear differentiation
between tumor-derived and CH-derived variants
Improved confidence
in clinically actionable findings
Seamless delivery
of CH insights as part of the Northstar Select Report
Download Helpful Resources
BillionToOne internal data on file, Jan 2026
Pascual, J., et al. ESMO recommendations on the use of ctDNA assays... Ann Oncol. 2022 Aug;33(8):750-768. PMID: 35809752.
Lockwood, CM., et al. A Joint Consensus Recommendation of AMP and CAP... Mol Diagn. 2023 Dec;25(12):876-897. doi: 10.1016/j.jmoldx.2023.09.004. Epub 2023 Oct 6. PMID: 37806433.
Marshall CH, et al. Cancer Res. 2022 Nov 15;82(22):4107-4113. PMID:36040522.
Coombs, CC., et al. Cell Stem Cell. 2017 Sep 7;21(3):374-382.e4. Epub 2017 Aug 10. PMID: 28803919
Magee D, et al. Clin Cancer Res. 2025 Jul 1;31(13):2710-2718. PMID: 39932457.
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